Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment
نویسندگان
چکیده
منابع مشابه
Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment
Radiotherapy sensitizes unresponsive tumors to the antineoplastic activity of antibodies that target the inhibitory receptor CTLA-4 on T cells. One molecular mechanism accounting for this therapeutic synergy is the induction of NKG2D ligands on irradiated tumor cells. The fact that NKG2D receptors must be engaged for the elicitation of CD8+ T-cell antitumor responses has important clinical impl...
متن کاملfrom linguistics to literature: a linguistic approach to the study of linguistic deviations in the turkish divan of shahriar
chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...
15 صفحه اولextensions of some polynomial inequalities to the polar derivative
توسیع تعدادی از نامساوی های چند جمله ای در مشتق قطبی
15 صفحه اولMutagen treatment as a means for selecting immunogenic variants from otherwise poorly immunogenic malignant murine tumors.
The selection of nontumorigenic (turn'), highly immunogenic variants from four different tumorigenic but poorly immuno genic murine tumors by mutagen treatment and cloning is described. Several factors were found to determine the suc cessful nature of this selection procedure including: the nature of the tumor used; the nature of the mutagen; the number of mutagen treatments; and the time at wh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: OncoImmunology
سال: 2013
ISSN: 2162-402X
DOI: 10.4161/onci.23127